The Mercedes-Benz E-Class has always been the core of the brand’s sedan lineup, blending luxury, innovation, and everyday practicality. The 2025 E450 4MATIC takes that formula to the next level. In Canada, it hits the sweet spot between the more affordable E350 and the high-performance AMG models. With a powerful mild-hybrid inline-six engine, smooth handling, and one of the best interiors in its class, the E450 offers a near-perfect balance of comfort and performance, making it one of the best luxury sedans you can buy today.
Performance
Under the hood, the 2025 E450 comes with a 3L turbocharged inline-six paired with a 48-volt mild-hybrid system. It makes 375 horsepower and 369 lb-ft of torque, with an extra 23 hp available during acceleration from the integrated starter-generator. The result is good power that makes the car feel quick and refined. Mercedes claims a 0–100 km/h time of just under 4.7 seconds, which is impressive for a midsize luxury sedan that isn’t an AMG.
The 9-speed automatic transmission delivers quick and seamless shifts, whether you’re driving in Comfort mode or Sport+. Throttle response is immediate, and power builds steadily, giving the E450 a confident, composed feel. The mild-hybrid system doesn’t just improve performance, it also helps smooth out start-stop function and improves efficiency in city traffic.
Handling in the 2025 E450 is just as refined as its powertrain. The steering is precise and well-weighted, giving you a solid sense of control without feeling overly heavy. The car stays composed through corners, with minimal body roll thanks to a well-tuned suspension that balances comfort and agility. Even in sharper turns or quick lane changes, the E450 feels stable and confident, helped by the 4MATIC all-wheel drive system and rear-biased setup. Mercedes’s 4MATIC all-wheel drive also comes standard across the lineup, which is a big plus for Canadians dealing with snow, rain, or slushy roads. It’s rear-biased under normal conditions, but can send power to the front wheels when needed, keeping the car balanced and responsive through corners like a true sport sedan.
Interior, Comfort, and Practicality
Inside, the E450 blends luxury with modern tech. The centrepiece in the cabin is the Mercedes-Benz Superscreen, which pairs a 12.3-inch digital instrument cluster with a 14.4-inch central touchscreen, both powered by the latest MBUX 7.0 infotainment system. There’s also an optional passenger display, allowing front passengers to stream video or adjust media without distracting the driver, thanks to a smart pixel-blocking feature.
The MBUX system supports natural voice commands, just say “Hey Mercedes”, and includes built-in apps like Spotify and YouTube, over-the-air updates, and even a selfie camera for video calls when parked. Wireless Apple CarPlay and Android Auto are smooth and intuitive, and the system’s haptic feedback helps reduce missed inputs while driving.
Material quality in the cabin is top-tier. The cabin features soft leather, open-pore wood, aluminum controls, and customizable ambient lighting that responds to music and drive modes. Heated and ventilated front seats are standard, with massage functions and memory settings. In the back, passengers get a lot of legroom and their own climate controls.
While the E450 offers generous headroom and legroom in both rows, the center console feels more focused on style than practicality. When the cupholders are in use, the space can get cramped, making it harder to store everyday items like your phone, wallet, or keys. It’s a small compromise in an otherwise well-designed interior, but one that is noticeable during daily use. The trunk, however, is quite spacious. With 540L of cargo space, the E450 offers plenty of room for luggage, groceries, or gear. The split-folding rear seats add flexibility, making it easy to load longer or bulkier items when needed.
Real-World Fuel Efficiency
Despite its strong performance and standard all-wheel drive, the E450 4MATIC remains impressively efficient. It’s rated at around 10.2 L/100 km in the city and 7.7 L/100 km on the highway, which is competitive for a midsize luxury sedan with this level of power. The mild-hybrid system helps keep fuel use in check by shutting off the engine at stoplights and even allowing the car to coast with the engine off on the highway. This makes the E450 surprisingly efficient in real-world driving, especially if your commute includes a lot of stop-and-go traffic.
The 2025 Mercedes-Benz E450 4MATIC doesn’t just meet expectations, it elevates them. It’s faster than most people will ever need, more comfortable than many rivals, and packed with thoughtful tech that enhances the driving and ownership experience. It blends traditional Mercedes comfort with a level of digital sophistication that feels ready for the next decade.
